2. Signaling Pathways
  3. Neuronal Signaling
  4. Sigma Receptor
  5. Sigma 2 Receptor Isoform
  6. Sigma 2 Receptor Inhibitor

Sigma 2 Receptor Inhibitor

Sigma 2 Receptor Inhibitor (1):

Cat. No. Product Name Effect Purity
  • HY-129215
    RTI-371
    		Inhibitor
    RTI-371 is a highly selective atypical dopamine transporter (DAT) inhibitor that crosses the blood-brain barrier. RTI-371 exhibits potent inhibitory activity in cell lines transfected with human DAT (IC50 = 8.7 nM) and shows high binding affinity for rat DAT with a Ki value of 7.81 nM. RTI-371 also acts as a positive allosteric modulator of the human cannabinoid 1 receptor (hCB1 receptor), enhancing the activity of cannabinoid receptor agonists in a concentration-dependent manner. RTI-371 can be used for the research of stimulant abuse and Parkinson's disease.